Human CCL8 Protein

Name: Human CCL8 Protein
Brand: 普维拓生物
SKU: CCL8-HP001

货号CCL8-HP001

HumanE. coli分子名 · HC14理论分子量 · 8.91 kDa

产品简介

Recombinant Human CCL8 Protein is expressed in E. coli without tag. It contains amino acid residues Gln24-Pro99 (UniProt accession: P80075).

产品详情

分子别名: HC14; MCP-2; MCP2; SCYA10; SCYA8
蛋白长度: Gln24-Pro99
表达系统: E. coli
理论分子量: The protein has a predicted MW of 8.91 kDa. The protein migrates to 12-14 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
状态: 冻干粉
储存条件: -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
复溶建议: Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

数据展示

Bis-Tris PAGE Data — Human CCL8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

背景介绍

C-C motif Chemokine ligand 8 (CCL8) has been found in diseases' pathogenesis. Exogenous CCL8 enhanced the proliferative and migration potential of LE cells and their motility in the environment with its stable concentration.of all the examined factors, chemokine CCL8 participates in the establishment of a proper environment for embryo implantation.

文献引用

1.Dai S, Zhang J, Xu Z. Silencing CCL8 inhibited the proliferation and migration of PDGF-BB-stimulated human aortic smooth muscle cells. Biosci Biotechnol Biochem. 2020 Aug;84(8):1585-1593. doi: 10.1080/09168451.2020.1762160. Epub 2020 May 20. PMID: 32432500.
2.Złotkowska A, Andronowska A. Chemokines as the modulators of endometrial epithelial cells remodelling. Sci Rep. 2019 Sep 10;9(1):12968. doi: 10.1038/s41598-019-49502-5. Erratum in: Sci Rep. 2019 Oct 3;9(1):14467. PMID: 31506569; PMCID: PMC6736846.