Human CCL11 Protein

Name: Human CCL11 Protein
Brand: 普维拓生物
SKU: CCL11-HP001

货号CCL11-HP001

HumanE. coli分子名 · Eotaxin理论分子量 · 9.46 kDa

产品简介

Recombinant Human CCL11 Protein is expressed in E. coli with a His tag at the N-terminus. It contains amino acid residues Gly24-Pro97 (UniProt accession: P51671).

产品详情

分子别名: Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11; SCYA11; eotaxin-1
蛋白长度: Gly24-Pro97
表达系统: E. coli
理论分子量: The protein has a predicted MW of 9.46 kDa. The protein migrates to 13-15 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in 20mM PB, 500mM NaCl, 200mM L-arginine (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Human CCL11 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

背景介绍

The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders.

文献引用

1.Parajuli B, Horiuchi H, Mizuno T, Takeuchi H, Suzumura A. CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia. Glia. 2015 Dec;63(12):2274-84. doi: 10.1002/glia.22892. Epub 2015 Jul 17. PMID: 26184677.

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Human CCL11 Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

背景介绍

文献引用

Human CCL11 Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

背景介绍

文献引用