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Recombinant Mouse B7-H4 Protein is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Leu25-Gly257 (UniProt accession: Q7TSP5).
B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status.
