FITC-Labeled Human B7-H3 (2Ig)/CD276 Protein

Name: FITC-Labeled Human B7-H3 (2Ig)/CD276 Protein
Brand: 普维拓生物
SKU: B7H3-HP012

货号B7H3-HP012

HumanHEK293分子名 · B7H3理论分子量 · 50.1 kDa

产品简介

Recombinant FITC-Labeled Human B7-H3/CD276 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Leu29-Pro245 (UniProt accession: Q5ZPR3-2).

产品详情

分子别名: B7H3; B7-H3; CD276; PSEC0249; UNQ309; PRO352; B7 homolog 3; CD276
蛋白长度: Leu29-Pro245
表达系统: HEK293
理论分子量: The protein has a predicted MW of 50.1 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in PBS (pH 7.4).
储存条件: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — FITC-Labeled Human B7-H3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

背景介绍

B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.

文献引用

1.Fodstad O, Tekle C, Chen Y W. The Immunoregulatory Protein Human B7H3 is a Tumor-Associated Antigen that Regulates Tumor Cell Migration and Invasion[J]. Current Cancer Drug Targets, 2008, 8(5)
2.Du H, Hirabayashi K, Ahn S, et al. Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells[J]. Cancer Cell, 2019, 35(2).

加载中…

FITC-Labeled Human B7-H3 (2Ig)/CD276 Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

背景介绍

文献引用

FITC-Labeled Human B7-H3 (2Ig)/CD276 Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

背景介绍

文献引用