Human CX3CR1 VLP Protein

Name: Human CX3CR1 VLP Protein
Brand: Puweituo Bio
SKU: CX3CR1-HP001

Catalog numberCX3CR1-HP001

HumanHEK293Molecule · CX3C chemokine receptor 1Molecular weight · 41.6 kDa

Product introduction

Human CX3CR1 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human CX3CR1 VLP is expressed from HEK293. It contains Met1-Leu355 (It may have cross reaction with anti-His antibody) (accession: P49238-1).

Product details

Molecular aliases: CX3C chemokine receptor 1; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; V28; CMKBRL1; GPR13; GPRV28
Protein length: Met1-Leu355
Expression system: HEK293
Molecular weight: The target protein has a predicted MW of 41.6 kDa.
Purity: > 90% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22μm filtered solution in PBS, 150mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

CX3CR1, also known as G-protein coupled receptor 13, is a receptor of CX3CL1. It is primarily expressed on monocytes, macrophages, dendritic cells, T cells, and natural killer cells. The binding of CX3CL1 to CX3CR1 induces the activation of heterotrimeric G proteins associated with this receptor. In addition, it triggers the signal pathways of MAPK and AKT, which play essential roles in tumour biology.

References

1.Lu X. Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer. Curr Med Chem. 2022;29(41):6228-6246. doi: 10.2174/0929867329666220629140540. PMID: 35770395.

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