Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer Protein

Name: Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer Protein
Brand: 普维拓生物
SKU: SURVIVIN-HB002

货号SURVIVIN-HB002

HumanHEK293分子名 · Survivin理论分子量 · 50.44 kDa

产品简介

Recombinant Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and LTLGEFLKL peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) & LTLGEFLKL).

产品详情

分子别名: Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha
蛋白长度: Gly25-Thr305
表达系统: HEK293
理论分子量: The protein has a predicted MW of 50.44 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer, His Tag at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 10.9ng/ml determined by ELISA (QC Test).

背景介绍

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.

文献引用

1.(1) Wheatley SP, Altieri DC. Survivin at a glance. J Cell Sci. 2019 Apr 4;132(7):jcs223826. doi: 10.1242/jcs.223826. PMID: 30948431; PMCID: PMC6467487.

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Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer Protein

货号SURVIVIN-HB002

HumanHEK293分子名 · Survivin理论分子量 · 50.44 kDa

Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用

Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用