Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein

Name: Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein
Brand: 普维拓生物
SKU: KRASWT-HB006

货号KRASWT-HB006

HumanE. coli分子名 · MHC理论分子量 · 35.36 kDa

产品简介

Recombinant Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and VVGAGGVGK peptide (accession: AAV53343.1 (HLA-A*11:01) & P61769 (B2M) &VVGAGGVGK).

产品详情

分子别名: MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
蛋白长度: Gly25-Thr305
表达系统: E. coli
理论分子量: The protein has a predicted MW of 35.36 kDa (HLA-A*11:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in 20 mM Tris, 200 mM NaCl (pH 8.0).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer, His-Avi tag at 1 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 28.6 ng/ml determined by ELISA (QC Test).

背景介绍

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.

文献引用

1.Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.

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Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein

货号KRASWT-HB006

HumanE. coli分子名 · MHC理论分子量 · 35.36 kDa

Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用

Biotinylated Human HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用