APC-Labeled Human HLA-C*05:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein

Name: APC-Labeled Human HLA-C*05:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein
Brand: 普维拓生物
SKU: KRASG12D-HP017

货号KRASG12D-HP017

HumanHEK293分子名 · MHC

产品简介

Recombinant APC-Labeled Human HLA-C*05:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. APC-Labeled Human HLA-C*05:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer is assembled by biotinylated monomer and APC-Labeled streptavidin. It contains Cys25-Ala366(HLA-C*05:01), Ile21-Met119(B2M) and GADGVGKSAL peptide (accession: AAD11469.1(HLA-C*05:01) & P61769(B2M) &GADGVGKSAL).

产品详情

分子别名: MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
蛋白长度: Cys25-Ala366
表达系统: HEK293
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
储存条件: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

背景介绍

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

文献引用

1.(1) Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.

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