Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer Protein

Name: Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer Protein
Brand: 普维拓生物
SKU: HPV16E7-HP004

货号HPV16E7-HP004

HumanHEK293分子名 · HPV16; E7; MHC;理论分子量 · 50.39 kDa

产品简介

Recombinant Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and IVCPICSQK peptide (accession: AAV53343.1(HLA-A*11:01) & P61769(B2M) &IVCPICSQK).

产品详情

分子别名: HPV16; E7; MHC;
蛋白长度: Gly25-Thr305
表达系统: HEK293
理论分子量: The protein has a predicted MW of 50.39 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
状态: 冻干粉
储存条件: -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
复溶建议: Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

数据展示

Bis-Tris PAGE Data — Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer is greater than 95% as determined by SEC-HPLC.

背景介绍

HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KDEL) to the HPV16 E7-specific affibody.

文献引用

1.Jiang P, Wang L, Hou B, Zhu J, Zhou M, Jiang J, Wang L, Chen S, Zhu S, Chen J, Zhang L. A novel HPV16 E7-affitoxin for targeted therapy of HPV16-induced human cervical cancer. Theranostics. 2018 Jun 7;8(13):3544-3558. doi: 10.7150/thno.24607. PMID: 30026865; PMCID: PMC6037027.

加载中…

Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer Protein

货号HPV16E7-HP004

HumanHEK293分子名 · HPV16; E7; MHC;理论分子量 · 50.39 kDa

Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用

Human HLA-A*11:01&B2M&HPV16 E7 (IVCPICSQK) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用