Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein

Name: Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein
Brand: 普维拓生物
SKU: HLAA0201-HP011

货号HLAA0201-HP011

HumanE. coli分子名 · NPM1-CLAV (CLAVEEVSL)理论分子量 · 35.6 kDa

产品简介

Recombinant Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &CLAVEEVSL).

产品详情

分子别名: NPM1-CLAV (CLAVEEVSL); NPM1-CLAV; CLAVEEVSL;
蛋白长度: Gly25-Thr305
表达系统: E. coli
理论分子量: The protein has a predicted MW of 35.6 kDa (HLA-A*02:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in 20mM Tris, 200mM NaCl (pH 8.0).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer is greater than 95% as determined by SEC-HPLC.

背景介绍

The nucleophosmin (NPM1) mutant protein, a leukemia-associated antigen characterized by its leukemia-restricted expression and immunogenic potential, has emerged as a promising therapeutic target for acute myeloid leukemia (AML) immunotherapy. Among its immunogenic epitopes, the CLAVEEVSL peptide derived from the full C-terminal region of the NPM1-mutated isoform demonstrates potent immunogenicity, making it a prime candidate for T cell-based immunotherapies.

文献引用

1.[1] Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia. DOI: 10.18632/oncotarget.26617
2.[2] Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia. DOI: 10.3390/ijms22179159

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Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein

货号HLAA0201-HP011

HumanE. coli分子名 · NPM1-CLAV (CLAVEEVSL)理论分子量 · 35.6 kDa

Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用

Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用