Biotinylated Human Claudin 4 Nanodisc Protein

Name: Biotinylated Human Claudin 4 Nanodisc Protein
Brand: 普维拓生物
SKU: CLDN4-HB001

货号CLDN4-HB001

HumanHEK293分子名 · Claudin-4

产品简介

Biotinylated Human Claudin 4 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human Claudin 4 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val209 (accession: O14493).

产品详情

分子别名: Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8
蛋白长度: Met1-Val209
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

文献引用

1.Fujiwara-Tani R, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Kondoh M, Kuniyasu H. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy. Int J Mol Sci. 2023 Mar 13;24(6):5494. doi: 10.3390/ijms24065494. PMID: 36982569; PMCID: PMC10051602.

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