Biotinylated Human CCR2b VLP Protein

Name: Biotinylated Human CCR2b VLP Protein
Brand: 普维拓生物
SKU: CCR2-HB001

货号CCR2-HB001

HumanHEK293分子名 · C-C CKR-2理论分子量 · 42.9 kDa

产品简介

Biotinylated Human CCR2b VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. The construct is expressed in HEK293 cells and contains the indicated native protein sequence.

产品详情

分子别名: C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2
蛋白长度: Met1-Leu360
表达系统: HEK293
理论分子量: 42.9 kDa
纯度: >95% (HPLC)
内毒素: <1 EU/μg (LAL assay)
缓冲液 / 制剂: 0.22 μm filtered solution in PBS with 300 mM L-arginine, pH 7.4.
储存条件: Store at -80°C for up to 12 months. Aliquot where appropriate and minimize freeze-thaw cycles.
阴性对照: GPR-HM05CB

背景介绍

The chemokine receptor CCR2B is an isoform of the receptor for CCL2, a major monocyte chemoattractant involved in inflammatory signaling. Filamin A associates with the CCR2B C-terminal region and contributes to receptor internalization and membrane localization.

文献引用

1.Minsaas L, Planagumà J, Madziva M, et al. Filamin A binds to CCR2B and regulates its internalization. PLoS One. 2010;5(8):e12212. doi:10.1371/journal.pone.0012212. PMID: 20808917.

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