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Recombinant Human BDCA-2 Protein is expressed in HEK293 cells with an mFc (IgG2a) tag at the N-terminus. It contains amino acid residues Phe46-Ile213 (UniProt accession: Q8WTT0-1).
BDCA-2 is a novel type II C-type lectin specifically expressed by plasmacytoid dendritic cells (PDCs) that can internalize antigen for presentation to T cells. Furthermore, signaling via BDCA-2 may play a role in switching from interferon (IFN)-α/β-controlled to interleukin (IL)-12-controlled immune response pathways, as triggering of BDCA-2 potently inhibits secretion of IFN-α/β by PDCs and thereby promotes IL-12 p70 production in PDCs and other cells.
