Human TM4SF1 Nanodisc Protein

Name: Human TM4SF1 Nanodisc Protein
Brand: Puweituo Bio
SKU: TM4SF1-HP002

Catalog numberTM4SF1-HP002

HumanHEK293Molecule · M3S1; TAAL6; H-L6; L6

Product introduction

Human TM4SF1 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human TM4SF1 Nanodisc is expressed from HEK293 with His tag at the N-terminus (FITC-equivalent protein is fused on cytoplasmic part). It contains Met1-Cys202 (accession: P30408).

Product details

Molecular aliases: M3S1; TAAL6; H-L6; L6
Protein length: Met1-Cys202
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. It is upregulated in several epithelial cancers and is closely associated with poor prognosis.

References

1.Yang JC, Zhang Y, He SJ, Li MM, Cai XL, Wang H, Xu LM, Cao J. TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1. Sci Rep. 2017 Apr 3;7:45895. doi: 10.1038/srep45895. PMID: 28368050; PMCID: PMC5377454.

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