Anti-MASP2 Antibody (Narsoplimab Biosimilar)

Name: Anti-MASP2 Antibody (Narsoplimab Biosimilar)
Brand: Puweituo Bio
SKU: MASP2-AB001

Catalog numberMASP2-AB001

HumanHEK293Molecular weight · 48.7 kDa

Product introduction

Anti-MASP2 Antibody (Narsoplimab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target MASP2, reactivity Huma/Cynomolgus/Mouse/Rat, isotype Human IgG1-Kappa, source-listed application ELISA/SPR.

Product details

Expression system: HEK293
Molecular weight: 48.7 kDa and 22.6 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Narsoplimab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Narsoplimab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human MASP2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Narsoplimab Biosimilar with the EC50 of 5.2ng/ml determined by ELISA. (QC Test)

Background

Te MASP2 gene is located on the chromosome 1p36.23–31 and encodes two proteins, MASP-2 and Map198. Both the levels and function of MASP-2 are modulated by the single-nucleotide polymorphisms (SNPs) of the MASP2 gene. Te level of MASP-2 in plasma plays a dual role in the infection and progression of infectious diseases. Te defciency of MASP-2 in plasma has been associated with the susceptibility of HIV. By contrast, the overproduction of MASP-2 may increase the infammatory efect.

References

1.Li Z, Wang M, Zhong H, Huang X, Wu X, Zhang X, Wang J, Deng J, Chen M, Chen L, Tan H. Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis. Sci Rep. 2021 Mar 22;11(1):6544. doi: 10.1038/s41598-021-86129-x. PMID: 33753877; PMCID: PMC7985323.

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Anti-MASP2 Antibody (Narsoplimab Biosimilar)

Catalog numberMASP2-AB001

HumanHEK293Molecular weight · 48.7 kDa

Anti-MASP2 Antibody (Narsoplimab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-MASP2 Antibody (Narsoplimab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References