Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer Protein

Name: Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer Protein
Brand: Puweituo Bio
SKU: HLAA0201-HP007

Catalog numberHLAA0201-HP007

HumanE. coliMolecule · KMQGAPPAV; MTMR5Molecular weight · 35.6 kDa

Product introduction

Recombinant Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and KMQGAPPAV peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &KMQGAPPAV).

Product details

Molecular aliases: KMQGAPPAV; MTMR5
Protein length: Gly25-Thr305
Expression system: E. coli
Molecular weight: The protein has a predicted MW of 35.6 kDa (HLA-A*02:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in 20 mM Tris, 200 mM NaCl (pH 8.0).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 9.0ng/ml determined by ELISA (QC Test).

Background

The human SBF1 (SET binding factor 1) gene, alternatively known as MTMR5, is predominantly expressed in the brain, and its epigenetic dysregulation is linked to late-onset neurocognitive disorders (NCDs), such as Alzheimer's disease.

References

1.Khamse S, Alizadeh S, Bernhart SH, Afshar H, Delbari A, Ohadi M. A (GCC) repeat in SBF1 reveals a novel biological phenomenon in human and links to late onset neurocognitive disorder. Sci Rep. 2022 Sep 14;12(1):15480. doi: 10.1038/s41598-022-19878-y. PMID: 36104480; PMCID: PMC9474449.

加载中…

Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer Protein

Catalog numberHLAA0201-HP007

HumanE. coliMolecule · KMQGAPPAV; MTMR5Molecular weight · 35.6 kDa

Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Human HLA-A*02:01&B2M&MTMR5 (KMQGAPPAV) Monomer Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References