Biotinylated Canine TSLP (R127A, R130A) Protein

Name: Biotinylated Canine TSLP (R127A, R130A) Protein
Brand: Puweituo Bio
SKU: TSLP-DB001

Catalog numberTSLP-DB001

HEK293Molecule · thymic stromal lymphopoietinMolecular weight · 17.25 kDa

Product introduction

Recombinant Biotinylated Canine TSLP (R127A, R130A) Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Tyr28-Ser154(R126A, R129A) (accession: I1VWC7).

Product details

Molecular aliases: thymic stromal lymphopoietin; TSLP
Protein length: Tyr28-Ser154
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 17.25 kDa. Due to glycosylation, the protein migrates to 18-20 kDa based on Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Biotinylated Canine TSLP (R127A, R130A) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Biotinylated Canine TSLP (R127A, R130A) is greater than 95% as determined by SEC-HPLC.

Background

Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells.

References

1.Corren J, Parnes J R, Wang L, et al. Tezepelumab in Adults with Uncontrolled Asthma[J]. New England Journal of Medicine, 2017, 377(10):936-946.

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Biotinylated Canine TSLP (R127A, R130A) Protein

Catalog numberTSLP-DB001

HEK293Molecule · thymic stromal lymphopoietinMolecular weight · 17.25 kDa

Biotinylated Canine TSLP (R127A, R130A) Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References

Biotinylated Canine TSLP (R127A, R130A) Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References