Anti-PSMA Antibody (Rosopatamab Biosimilar)

Name: Anti-PSMA Antibody (Rosopatamab Biosimilar)
Brand: Puweituo Bio
SKU: PSMA-AB001

Catalog numberPSMA-AB001

HumanHEK293Molecular weight · 50.9 kDa

Product introduction

Anti-PSMA Antibody (Rosopatamab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target PSMA, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 50.9 kDa and 23.4 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Rosopatamab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Rosopatamab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human PSMA, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Rosopatamab Biosimilar with the EC50 of 4.1ng/ml determined by ELISA. (QC Test)

Background

Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells.

References

1.Song C, Francesca Z, Williams D G, et al. Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-drug Conjugate Targeting PSMA, in Pre-clinical Models of Prostate Cancer[J]. Molecular Cancer Therapeutics, 2018:molcanther.0982.2017-.

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Anti-PSMA Antibody (Rosopatamab Biosimilar)

Catalog numberPSMA-AB001

HumanHEK293Molecular weight · 50.9 kDa

Anti-PSMA Antibody (Rosopatamab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-PSMA Antibody (Rosopatamab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References