PE-Labeled Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Tetramer Protein

Name: PE-Labeled Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Tetramer Protein
Brand: Puweituo Bio
SKU: MAGEA10-HP003

Catalog numberMAGEA10-HP003

HumanHEK293Molecule · MAGE-A10

Product introduction

Recombinant PE-Labeled Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. PE-Labeled Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin. It contains Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and GLYDGMEHL peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &GLYDGMEHL).

Product details

Molecular aliases: MAGE-A10
Protein length: Gly25-Thr305
Expression system: HEK293
Formulation: Lyophilized from 0.22 μm filtered solution in PBS, 0.2% BSA (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
State: Lyophilized
Storage: -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Reconstitution: Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

Background

MAGE-A10 is a subtype of the Melanoma-associated antigen A (MAGE-A), a class of tumor antigens that are extensively expressed in various histological types of tumors and represents an attractive target for tumor immunotherapy. High-level expression of MAGE-A10 improved the anti-tumor immune cytotoxicity of MAGE-A10-specific CTLs in lung cancer cell lines and primary lung cancer cells.

References

1.Li Z, Guo P, Guo P, Dong K, Liu F, Wu Y, Li J, Shan B, Sang M. 5-aza-2'-deoxycytidine (DAC) treatment induces the MAGE-A10 expression and improves the cytotoxicity of MAGE-A10-specific CTLs in lung cancer cells. Transl Cancer Res. 2020 Feb;9(2):1235-1245. doi: 10.21037/tcr.2020.01.10. PMID: 35117468; PMCID: PMC8798493.

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PE-Labeled Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Tetramer Protein

Catalog numberMAGEA10-HP003

HumanHEK293Molecule · MAGE-A10