Human LGR-4 Nanodisc Protein

Name: Human LGR-4 Nanodisc Protein
Brand: Puweituo Bio
SKU: LGR4-HP001

Catalog numberLGR4-HP001

HumanHEK293Molecule · LGR4; GPR48

Product introduction

Human LGR-4 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human LGR-4 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Asp951 (accession: Q9BXB1-1).

Product details

Molecular aliases: LGR4; GPR48
Protein length: Met1-Asp951
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

Leucine-rich repeat-containing G protein-coupled receptor (LGR)-4 is a G protein-coupled receptor (GPCR) with a seven-transmembrane domain structure. LGRs are evolutionally and structurally phylogenetic, classified into three subgroups and are members of the so-called orphan receptors.

References

1.Kato S, Matsubara M, Matsuo T, Mohri Y, Kazama I, Hatano R, Umezawa A, Nishimori K. Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 2006;104(2):e63-75. doi: 10.1159/000093999. Epub 2006 Jun 19. PMID: 16785743.

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