Biotinylated Human FcRL2/IRTA4 Protein (Primary Amine Labeling)

Name: Biotinylated Human FcRL2/IRTA4 Protein (Primary Amine Labeling)
Brand: Puweituo Bio
SKU: IRTA4-HB001

Catalog numberIRTA4-HB001

HumanHEK293Molecule · FcR-like protein 2Molecular weight · 42.7 kDa

Product introduction

Recombinant Biotinylated Human FcRL2/IRTA4 Protein (Primary Amine Labeling) is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Leu20-Val401 (UniProt accession: Q96LA5-1).

Product details

Molecular aliases: FcR-like protein 2; FcRL2; FCRH2; IFGP4; IRTA4; FCRL2; CD307b; FCRH2SPAP1B; IRTA4SPAP1C; SPAP1; SPAP1A
Protein length: Leu20-Val401
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 42.7 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Biotinylated Human FcRL2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ELISA Data — Immobilized Biotinylated Human FcRL2, His Tag at 2μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-FcRL2 Antibody, hFc Tag with the EC50 of 28.2ng/ml determined by ELISA (QC Test).

Background

Fc receptor-like 2 (FCRL2) is highly expressed on B-cell chronic lymphocytic leukemia (B-CLL) cells and could possibly influence disease pathogenesis. FCRL2 mRNA expression was found to be expressed at considerably higher levels in peripheral blood mononuclear cells (PBMC) of B-CLL patients compared to controls (range 1.35- to 210-fold upregulation; P < 0.0001) and cells of other hematological diseases.

References

1.Nückel H, Collins CH, Frey UH, Sellmann L, Dürig J, Siffert W, Dührsen U. FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia. Eur J Haematol. 2009 Dec 1;83(6):541-9. doi: 10.1111/j.1600-0609.2009.01328.x. Epub 2009 Aug 4. PMID: 19682311.

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Biotinylated Human FcRL2/IRTA4 Protein (Primary Amine Labeling)

Catalog numberIRTA4-HB001

HumanHEK293Molecule · FcR-like protein 2Molecular weight · 42.7 kDa

Biotinylated Human FcRL2/IRTA4 Protein (Primary Amine Labeling)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

ELISA

ELISA Data

Background

References

Biotinylated Human FcRL2/IRTA4 Protein (Primary Amine Labeling)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

ELISA

ELISA Data

Background

References