PE-Labeled Cynomolgus HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein

Name: PE-Labeled Cynomolgus HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein
Brand: Puweituo Bio
SKU: HLAG-HP003

Catalog numberHLAG-HP003

HEK293Molecule · HLA G antigen

Product introduction

Recombinant PE-Labeled Cynomolgus HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus, PE-Labeled Cynomolgus HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin. It contains Gly25-Thr305(HLA-G), Ile21-Met119(B2M) and RIIPRHLQL peptide (accession: E0WKX9(HLA-G) & Q8SPW0(B2M) &RIIPRHLQL).

Product details

Molecular aliases: HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
Protein length: Gly25-Thr305
Expression system: HEK293
Formulation: Supplied as 0.22 μm filtered solution in PBS, 100mM L-Arginine, 0.2%BSA (pH 7.4).
Storage: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.

References

1.(1) Krijgsman D, Roelands J, Hendrickx W, Bedognetti D, Kuppen PJK. HLA-G: A New Immune Checkpoint in Cancer? Int J Mol Sci. 2020 Jun 25;21(12):4528. doi: 10.3390/ijms21124528. PMID: 32630545; PMCID: PMC7350262.

加载中…