Biotinylated Human GIPR Nanodisc Protein

Name: Biotinylated Human GIPR Nanodisc Protein
Brand: Puweituo Bio
SKU: GIPR-HB001

Catalog numberGIPR-HB001

HumanHEK293Molecule · GIP-R; GIPR; PGQTL2

Product introduction

Biotinylated Human GIPR Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human GIPR Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Cys466 (accession: P48546-1).

Product details

Molecular aliases: GIP-R; GIPR; PGQTL2
Protein length: Met1-Cys466
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

The gastric inhibitory polypeptide receptor (GIPR), a G protein-coupled receptor (GPCR) that regulates glucose metabolism and insulin secretion, is a target for the development of therapeutic agents to address type 2 diabetes and obesity.

References

1.Brown KA, Morris RK, Eckhardt SJ, Ge Y, Gellman SH. Phosphorylation Sites of the Gastric Inhibitory Polypeptide Receptor (GIPR) Revealed by Trapped-Ion-Mobility Spectrometry Coupled to Time-of-Flight Mass Spectrometry (TIMS-TOF MS). J Am Chem Soc. 2023 Dec 27;145(51):28030-28037. doi: 10.1021/jacs.3c09078. Epub 2023 Dec 13. PMID: 38091482; PMCID: PMC10842860.

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