Human EDNRA VLP Protein

Name: Human EDNRA VLP Protein
Brand: Puweituo Bio
SKU: EDNRA-HP001

Catalog numberEDNRA-HP001

HumanHEK293Molecule · EDNRA

Product introduction

Human EDNRA VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human EDNRA VLP is expressed from HEK293. It contains Met1-Asn427 (It may have cross reaction with anti-His antibody) (accession: P25101-1).

Product details

Molecular aliases: EDNRA; ET-A; ETA-R; hET-AR; ETA; ETRA
Protein length: Met1-Asn427
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 150mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

The endothelin-A receptor (Ednra) is involved in several physiological, pathological, and developmental pathways. Known for its function in vasoconstriction after being activated by endothelin-1, Ednra also controls cephalic neural crest cell development and appears to play a role in several pathologies, including cancer and periodontitis.

References

1.Zhang Y, Knutsen GR, Brown MD, Ruest LB. Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2. Mol Endocrinol. 2013 Jun;27(6):892-908. doi: 10.1210/me.2012-1334. Epub 2013 Apr 16. PMID: 23592430; PMCID: PMC3656236.

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