Biotinylated Human DLL3 Domain (352-479) Protein

Name: Biotinylated Human DLL3 Domain (352-479) Protein
Brand: Puweituo Bio
SKU: DLL3-HB004

Catalog numberDLL3-HB004

HumanHEK293Molecule · Delta3Molecular weight · 17.30 kDa

Product introduction

Recombinant Biotinylated Human DLL3 Domain (352-479) Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Lys352-Ala479 (UniProt accession: Q9NYJ7-1).

Product details

Molecular aliases: Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3
Protein length: Lys352-Ala479
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 17.30 kDa. Due to glycosylation, the protein migrates to 20-25 kDa based on Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 100mM L-arginine (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Biotinylated Human DLL3 Domain (352-479) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

References

1.Saunders L R, Bankovich A J, Anderson W C, et al. A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo[J]. Science Translational Medicine, 2015.

加载中…

Biotinylated Human DLL3 Domain (352-479) Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

Background

References

Biotinylated Human DLL3 Domain (352-479) Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

Background

References