Biotinylated Human Claudin 6 Nanodisc Protein

Name: Biotinylated Human Claudin 6 Nanodisc Protein
Brand: Puweituo Bio
SKU: CLDN6-HB002

Catalog numberCLDN6-HB002

HumanHEK293Molecule · Claudin-6

Product introduction

Biotinylated Human Claudin 6 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human Claudin 6 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val220 (accession: P56747).

Product details

Molecular aliases: Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2
Protein length: Met1-Val220
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively.

References

1.(1) Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, Endo C, Tanaka S, Sawada N, Watabe T, Higashi T, Chiba H. Cell adhesion signals regulate the nuclear receptor activity. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24600-24609. doi: 10.1073/pnas.1913346116. Epub 2019 Nov 18. PMID: 31740618; PMCID: PMC6900646.

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