Cynomolgus Claudin 6 VLP Protein

Name: Cynomolgus Claudin 6 VLP Protein
Brand: Puweituo Bio
SKU: CLDN6-CP001

Catalog numberCLDN6-CP001

HEK293Molecule · Claudin-6Molecular weight · 24.60 kDa

Product introduction

Cynomolgus Claudin 6 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. The construct is expressed in HEK293 cells and contains Met1-Val220 (UniProt accession: G7Q0B0).

Product details

Molecular aliases: Claudin-6; Skullin; CLDN6; Claudin6; EGM_11390; Claudin
Protein length: Met1-Val220
Expression system: HEK293
Molecular weight: 24.60 kDa
Purity: >95% (HPLC)
Endotoxin: <1 EU/μg (LAL assay)
Formulation: 0.22 μm filtered solution in PBS with 300 mM L-arginine, pH 7.4.
Storage: Store at -80°C for up to 12 months. Aliquot where appropriate and minimize freeze-thaw cycles.
Negative control: VLP-HM00C

Background

Claudin-6 is a multi-pass transmembrane protein in the claudin family. It is expressed by epithelial cells and participates in tissue development and the maintenance of tight-junction integrity. Human Claudin-6 shares substantial sequence identity with the corresponding mouse and rat proteins.

References

1.Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, et al. Cell adhesion signals regulate the nuclear receptor activity. Proc Natl Acad Sci U S A. 2019;116(49):24600-24609. doi:10.1073/pnas.1913346116. PMID: 31740618.

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