Biotinylated Human Claudin 18.2 VLP Protein

Name: Biotinylated Human Claudin 18.2 VLP Protein
Brand: Puweituo Bio
SKU: CLDN182-HB001

Catalog numberCLDN182-HB001

HEK293Molecule · CLDN18Molecular weight · 29 kDa

Product introduction

Biotinylated Human Claudin 18.2 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. The construct is expressed in HEK293 cells and contains Met1-Val261 (UniProt accession: P56856-2).

Product details

Molecular aliases: CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ
Protein length: Met1-Val261
Expression system: HEK293
Molecular weight: 29 kDa
Purity: >95% (HPLC)
Endotoxin: <1 EU/μg (LAL assay)
Formulation: 0.22 μm filtered solution in PBS with 300 mM L-arginine, pH 7.4.
Storage: Store at -80°C for up to 12 months. Aliquot where appropriate and minimize freeze-thaw cycles.
Negative control: GPR-HM05CB

Background

Claudin-18 (CLDN18) is a member of the claudin family that forms tight-junction strands in epithelial cells. CLDN18 is expressed in stomach and lung tissues and has two splice variants, CLDN18.1 and CLDN18.2. Claudin-18.2 is enriched in gastric tumors.

References

1.Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer. J Hematol Oncol. 2017;10(1):105.

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