Anti-CD20 Antibody (Rituximab Biosimilar)

Name: Anti-CD20 Antibody (Rituximab Biosimilar)
Brand: Puweituo Bio
SKU: CD20-AB002

Catalog numberCD20-AB002

HumanHEK293Molecular weight · 49.2 kDa

Product introduction

Anti-CD20 Antibody (Rituximab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CD20, reactivity Human, isotype Human IgG1-Kappa, source-listed application ELISA/SPR/BLI.

Product details

Expression system: HEK293
Molecular weight: 49.2 kDa and 23.1 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Rituximab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Rituximab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human CD20 VLP at 5μg/ml (100μl/Well) on plate on the plate. Dose response curve for Rituximab Biosimilar with the EC50 of 8.6ng/ml determined by ELISA (QC Test)

Background

B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R, CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.

References

1.Ma D, Mcdevitt M R, Barendswaard E, et al. Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies[J]. Leukemia, 2002, 16(1):60-66.
2.Jager U, Fridrik M, Zeitlinger M, et al. Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response[J]. Haematologica, 2012, 97(9):1431-1438.

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Anti-CD20 Antibody (Rituximab Biosimilar)

Catalog numberCD20-AB002

HumanHEK293Molecular weight · 49.2 kDa

Anti-CD20 Antibody (Rituximab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-CD20 Antibody (Rituximab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References