Anti-CD19 Antibody (Denintuzumab Biosimilar)

Name: Anti-CD19 Antibody (Denintuzumab Biosimilar)
Brand: Puweituo Bio
SKU: CD19-AB002

Catalog numberCD19-AB002

HumanHEK293Molecular weight · 51.5 kDa

Product introduction

Anti-CD19 Antibody (Denintuzumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CD19, reactivity Human/Cynomolgus/Rhesus macaque, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 51.5 kDa and 23.2 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Denintuzumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Denintuzumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human CD19, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Denintuzumab Biosimilar with the EC50 of 8.6ng/ml determined by ELISA. (QC Test)

Background

CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses. Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2 stores.

References

1.Maude S L, Teachey D T, Porter D L, et al. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia[J]. Blood, 2015, 125(26):4017-23.

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Anti-CD19 Antibody (Denintuzumab Biosimilar)

Catalog numberCD19-AB002

HumanHEK293Molecular weight · 51.5 kDa

Anti-CD19 Antibody (Denintuzumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-CD19 Antibody (Denintuzumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References