Anti-B7-H3 Antibody (Enoblituzumab Biosimilar)

Name: Anti-B7-H3 Antibody (Enoblituzumab Biosimilar)
Brand: Puweituo Bio
SKU: B7H3-AB001

Catalog numberB7H3-AB001

HumanHEK293Molecular weight · 49.5 kDa

Product introduction

Anti-B7-H3 Antibody (Enoblituzumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target B7-H3, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 49.5 kDa and 23.5 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Enoblituzumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Enoblituzumab Biosimilar is greater than 90% as determined by SEC-HPLC.

ELISA Data — Immobilized Human B7-H3, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Enoblituzumab Biosimilar with the EC50 of 8.5ng/ml determined by ELISA. (QC Test)

Background

B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers. B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.

References

1.Du H, Hirabayashi K, Ahn S, et al. Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells[J]. Cancer Cell, 2019, 35(2).

加载中…

Anti-B7-H3 Antibody (Enoblituzumab Biosimilar)

Catalog numberB7H3-AB001

HumanHEK293Molecular weight · 49.5 kDa

Anti-B7-H3 Antibody (Enoblituzumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-B7-H3 Antibody (Enoblituzumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References