Human TSHR VLP Protein

Name: Human TSHR VLP Protein
Brand: Puweituo Bio
SKU: TSHR-HP001

Catalog numberTSHR-HP001

HumanHEK293Molecule · TSH-R; LGR3; TSH RMolecular weight · 87.81 kDa

Product introduction

Human TSHR VLP Protein is a full-length multi-pass membrane protein presented in a VLP format for antibody discovery, binding assays and method development. Recombinant Human TSHR VLP is expressed from HEK293. It contains Met1-Leu764 (It may have cross reaction with anti-His antibody) (accession: P16473).

Product details

Molecular aliases: TSH-R; LGR3; TSH R
Protein length: Met1-Leu764
Expression system: HEK293
Molecular weight: The target protein has a predicted MW of 87.81 kDa.
Purity: > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

Thyroid stimulating hormone receptor (TSHR) is a receptor for thyrostimulin and thyroid stimulating hormone (TSH, also called thyrotropin). TSHR is a cell surface glycoprotein receptor and belongs to the leucine-rich repeat (LGR) subfamily of G-protein-coupled receptors (GPCRs).

References

1.Chu YD, Yeh CT. The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells. Cells. 2020 Jul 20;9(7):1730. doi: 10.3390/cells9071730. PMID: 32698392; PMCID: PMC7407617.

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