Anti-TROP-2 Antibody (Sacituzumab Biosimilar)

Name: Anti-TROP-2 Antibody (Sacituzumab Biosimilar)
Brand: Puweituo Bio
SKU: TROP2-AB001

Catalog numberTROP2-AB001

HumanHEK293Molecular weight · 49.4 kDa

Product introduction

Anti-TROP-2 Antibody (Sacituzumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target TROP-2, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 49.4 kDa and 23.3 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Sacituzumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Sacituzumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human TROP-2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Sacituzumab Biosimilar with the EC50 of 2.2ng/ml determined by ELISA. (QC Test)

Background

Trop-2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

References

1.Goldenberg D M, Cardillo T M, Govindan S V, et al. Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)*[J]. Oncotarget, 2015, 6(26).

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Anti-TROP-2 Antibody (Sacituzumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-TROP-2 Antibody (Sacituzumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References