Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc Protein

Name: Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc Protein
Brand: Puweituo Bio
SKU: SLC7A11-HB001

Catalog numberSLC7A11-HB001

HumanHEK293Molecule · Cystine

Product introduction

Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Leu501 (accession: Q9UPY5).

Product details

Molecular aliases: Cystine / glutamate transporter; xCT; SLC7A11; CCBR1;
Protein length: Met1-Leu501
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) is the functional subunit of the Xc- system, an anionic L-cystine/L-glutamate antiporter expressed on the cell surface. SLC7A11 expression is significantly upregulated in several types of cancers in which it can inhibit ferroptosis and favor cancer cell proliferation, invasion and chemoresistance. SLC7A11 expression is also increased in ovarian cancer tissues, suggesting a possible role of this protein as a therapeutic target.

References

1.Fantone S, Piani F, Olivieri F, Rippo MR, Sirico A, Di Simone N, Marzioni D, Tossetta G. Role of SLC7A11/xCT in Ovarian Cancer. Int J Mol Sci. 2024 Jan 2;25(1):587. doi: 10.3390/ijms25010587. PMID: 38203758; PMCID: PMC10779187.

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Biotinylated Human Cystine/glutamate transporter (SLC7A11) Nanodisc Protein

Catalog numberSLC7A11-HB001

HumanHEK293Molecule · Cystine