Biotinylated Mouse PVRIG Protein

Name: Biotinylated Mouse PVRIG Protein
Brand: Puweituo Bio
SKU: PR432201

Cat. No.PR432201

Key advantages

High purity

Expression host / system: HEK293
Species: Mouse
Tags: —
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Contact for data package

Representative QC

Technical specifications

Species

Mouse

Synonym

C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

Source / expression

Recombinant Biotinylated Mouse PVRIG Protein is expressed from HEK293 with hFc (IgG1) tag and Avi tag at the C-Terminus.It contains Ser35-Asp165 [Accession | A0A1B0GS01].

Molecular weight

The protein has a predicted MW of 42.7 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.

Endotoxin

Less than 1 EU per μg by the LAL method.

Purity

> 95% as determined by Bis-Tris PAGE

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution

Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

Storage

-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

References

Murter B, Pan X, Ophir E, Alteber Z, Azulay M, Sen R, Levy O, Dassa L, Vaknin I, Fridman-Kfir T, Salomon R, Ravet A, Tam A, Levin D, Vaknin Y, Tatirovsky E, Machlenkin A, Pardoll D, Ganguly S. Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunol Res. 2019 Feb;7(2):244-256. doi: 10.1158/2326-6066.CIR-18-0460 Epub 2019 Jan 18. PMID: 30659055; PMCID: PMC7038785.

Background

Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG is an inducible checkpoint receptor and that targeting PVRIG-PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth.

FOLR1-PH1101

Non-biotinylated Human FOLR1 Protein

Biotinylated Mouse PVRIG Protein

Technical specifications

References

Background

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Biotinylated Mouse PVRIG Protein

Technical specifications

References

Background

Related products

Services & discovery