Anti-PCSK9 Antibody (Alirocumab Biosimilar)

Name: Anti-PCSK9 Antibody (Alirocumab Biosimilar)
Brand: Puweituo Bio
SKU: PCSK9-AB001

Catalog numberPCSK9-AB001

HumanHEK293Molecular weight · 50.68 kDa

Product introduction

Anti-PCSK9 Antibody (Alirocumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target PCSK9, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 50.68 kDa and 22.57 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Alirocumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Alirocumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human PCSK9, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Alirocumab Biosimilar with the EC50 of 0.13μg/ml determined by ELISA. (QC Test)

Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1. The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.

References

1.McKenney, James M. Understanding PCSK9 and anti-PCSK9 therapies[J]. Journal of Clinical Lipidology, 2015, 9(2):170-186.

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Anti-PCSK9 Antibody (Alirocumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-PCSK9 Antibody (Alirocumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References