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Recombinant Biotinylated Human MDL-1/CLEC5A Protein is expressed in HEK293 cells with a His tag and Avi tag at the N-terminus. It contains amino acid residues Pro28-Lys188 (UniProt accession: Q9NY25-1).
In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor. MDL-1, like its mammalian orthologs, is an inhibitor of cell proliferation and growth that slows progression of an age-related pathology in C. elegans (uterine tumors). In addition, intestine-limited rescue of mdl-1 increased lifespan but not to wild type levels. Thus, mdl-1 likely acts both in the intestine and the germline to influence age-related mortality.
