Anti-LRRC15 Antibody (Samrotamab Biosimilar)

Name: Anti-LRRC15 Antibody (Samrotamab Biosimilar)
Brand: Puweituo Bio
SKU: LRRC15-AB001

Catalog numberLRRC15-AB001

HumanHEK293Molecular weight · 51.7 kDa

Product introduction

Anti-LRRC15 Antibody (Samrotamab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target LRRC15, reactivity Human/Cynomolgus/Rhesus macaque/Mouse, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 51.7 kDa and 23.4 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Samrotamab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Samrotamab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human LRRC15, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Samrotamab Biosimilar with the EC50 of 6.5ng/ml determined by ELISA. (QC Test)

Background

The leucine-rich repeat-containing protein 15 (LRRC15) is involved in cell–cell and cell–matrix interactions and came into focus as a promising anticancer target owing to its overexpression in mesenchymal-derived tumors such as sarcoma, glioblastoma, and melanoma and in cancer-associated fibroblasts in the microenvironment of breast, head and neck, lung, and pancreatic tumors.

References

1.Ray U, Pathoulas CL, Thirusangu P, Purcell JW, Kannan N, Shridhar V. Exploiting LRRC15 as a Novel Therapeutic Target in Cancer. Cancer Res. 2022 May 3;82(9):1675-1681. doi: 10.1158/0008-5472.CAN-21-3734. PMID: 35260879; PMCID: PMC9064950.

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Anti-LRRC15 Antibody (Samrotamab Biosimilar)

Catalog numberLRRC15-AB001

HumanHEK293Molecular weight · 51.7 kDa

Anti-LRRC15 Antibody (Samrotamab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-LRRC15 Antibody (Samrotamab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References