Anti-Latent GDF-8 Antibody (Apitegromab Biosimilar)

Name: Anti-Latent GDF-8 Antibody (Apitegromab Biosimilar)
Brand: Puweituo Bio
SKU: LATENTGDF8-AB001

Catalog numberLATENTGDF8-AB001

HumanHEK293Molecular weight · 52.27 kDa

Product introduction

Anti-Latent GDF-8 Antibody (Apitegromab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Latent GDF-8, reactivity Human/Cynomolgus/Mouse/Rat, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 52.27 kDa and 22.55 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Apitegromab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Apitegromab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human Latent GDF-8, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Apitegromab Biosimilar with the EC50 of 23.1ng/ml determined by ELISA. (QC Test)

Background

Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain. GDF8, like numerous TGF-β family members, is a disulfidelinked dimer that is synthesized as a precursor protein which requires cleavage by a furin-like protease to yield an N-terminal prodomain and a C-terminal mature, signaling domain.

References

1.PMID: 29348202; PMCID: PMC5798348.

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Anti-Latent GDF-8 Antibody (Apitegromab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-Latent GDF-8 Antibody (Apitegromab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References