PE-Labeled Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein

Name: PE-Labeled Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein
Brand: Puweituo Bio
SKU: KRASG12D-HP013

Catalog numberKRASG12D-HP013

HumanHEK293Molecule · MHC

Product introduction

Recombinant PE-Labeled Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. PE-Labeled Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin. It contains Cys25-Ala366(HLA-C*08:01), Ile21-Met119(B2M) and GADGVGKSAL peptide (accession: AAA59688.1(HLA-C*08:01) & P61769(B2M) &GADGVGKSAL).

Product details

Molecular aliases: MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
Protein length: Cys25-Ala366
Expression system: HEK293
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
Storage: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

References

1.(1) Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.

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