PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein

Name: PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein
Brand: Puweituo Bio
SKU: KRASG12D-HP010

Catalog numberKRASG12D-HP010

HumanHEK293Molecule · MHC

Product introduction

Recombinant PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. PE-labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin. It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGADGVGK peptide (accession: AAV53343.1(HLA-A*11:01) & P61769(B2M) &VVVGADGVGK).

Product details

Molecular aliases: MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
Protein length: Gly25-Thr305
Expression system: HEK293
Formulation: Supplied as 0.22μm filtered solution in PBS, 0.2% BSA (pH 7.4).
Storage: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

ELISA Data — Immobilized HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1μg/ml (100μl/well) on the plate. Dose response curve for PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 96.7ng/ml determined by ELISA.

Background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

References

1.(1) Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.

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PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein

Catalog numberKRASG12D-HP010

HumanHEK293Molecule · MHC

PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein

Product introduction

Product details

Data display

ELISA

ELISA Data

Background

References

PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein

Product introduction

Product details

Data display

ELISA

ELISA Data

Background

References