Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein

Name: Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein
Brand: Puweituo Bio
SKU: KRASG12C-HP001

Catalog numberKRASG12C-HP001

HumanHEK293Molecule · MHCMolecular weight · 48.40 kDa

Product introduction

Recombinant Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein is expressed from HEK293 with His tag at the C-terminus. It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGACGVGK peptide (accession: AAV53343.1(HLA-A*11:01) & P61769(B2M) &VVVGACGVGK).

Product details

Molecular aliases: MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
Protein length: Gly25-Thr305
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 48.40 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer is greater than 95% as determined by SEC-HPLC.

Background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

References

1.(1) Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.

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Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein

Catalog numberKRASG12C-HP001

HumanHEK293Molecule · MHCMolecular weight · 48.40 kDa

Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References

Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References