Anti-Her3 Antibody (Patritumab Biosimilar)

Name: Anti-Her3 Antibody (Patritumab Biosimilar)
Brand: Puweituo Bio
SKU: HER3-AB001

Catalog numberHER3-AB001

HumanHEK293Molecular weight · 49.2 kDa

Product introduction

Anti-Her3 Antibody (Patritumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Her3, reactivity Human/Cynomolgus/Rhesus macaque, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 49.2 kDa and 24.3 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Patritumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Patritumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human Her3, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Patritumab Biosimilar with the EC50 of 3.2ng/ml determined by ELISA. (QC Test)

Background

Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG).

References

1.Yonesaka K, Haratani K, Hirotani K, et al. Abstract 44: U3-1402, a novel HER3-targeting ADC, and a novel DNA topoisomerase I inhibitor inhibit the growth of non-small cell lung cancer with EGFR mutation[J]. Cancer Research, 2017, 77(13 Supplement):44-44.

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Anti-Her3 Antibody (Patritumab Biosimilar)

Catalog numberHER3-AB001

HumanHEK293Molecular weight · 49.2 kDa

Anti-Her3 Antibody (Patritumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-Her3 Antibody (Patritumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References