加载中…
Anti-Her2 Antibody (Trastuzumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Her2, reactivity Human/Cynomolgus/Mouse, isotype Human IgG1-Kappa, source-listed application ELISA.
ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.
