Biotinylated Human GPRC5D VLP Protein

Name: Biotinylated Human GPRC5D VLP Protein
Brand: Puweituo Bio
SKU: GPRC5D-HB001

Catalog numberGPRC5D-HB001

HumanHEK293Molecule · GPRC5DMolecular weight · 39.6 kDa

Product introduction

Biotinylated Human GPRC5D VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human GPRC5D VLP is expressed from HEK293. It contains Met1-Val345 (It may have cross reaction with anti-His antibody) (accession: Q9NZD1-1).

Product details

Molecular aliases: GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
Protein length: Met1-Val345
Expression system: HEK293
Molecular weight: The target protein has a predicted MW of 39.6 kDa.
Purity: > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.

References

1.Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.

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