Anti-GDF15 Antibody (Ponsegromab Biosimilar)

Name: Anti-GDF15 Antibody (Ponsegromab Biosimilar)
Brand: Puweituo Bio
SKU: GDF15-AB001

Catalog numberGDF15-AB001

HumanHEK293Molecular weight · 51.26 kDa

Product introduction

Anti-GDF15 Antibody (Ponsegromab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target GDF15, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 51.26 kDa and 23.64 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Ponsegromab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Ponsegromab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human GDF15, His Tag at 0.5μg/ml(100μl/well) on the plate. Dose response curve for Ponsegromab Biosimilar with the EC50 of 10.9ng/ml determined by ELISA. (QC Test)

Background

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.

References

1.PMID: 31402172; PMCID: PMC6863354. Copy

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Anti-GDF15 Antibody (Ponsegromab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-GDF15 Antibody (Ponsegromab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References