Anti-FcRn Antibody (Rozanolixizumab Biosimilar)

Name: Anti-FcRn Antibody (Rozanolixizumab Biosimilar)
Brand: Puweituo Bio
SKU: FCRN-AB001

Catalog numberFCRN-AB001

HumanHEK293Molecular weight · 50.81 kDa

Product introduction

Anti-FcRn Antibody (Rozanolixizumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target FcRn, reactivity Human/Cynomolgus/Rhesus macaque, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 50.81 kDa and 23.88 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Rozanolixizumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Rozanolixizumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human FcRn, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Rozanolixizumab Biosimilar with the EC50 of 5.4 ng/ml determined by ELISA. (QC Test)

Background

The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT&B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14, and forms an MHC class I-like heterodimer.

References

1.Kiessling P, Lledo-Garcia R, Watanabe S, et al. The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study[J]. Science translational medicine, 2017, 9(414):eaan1208.

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Anti-FcRn Antibody (Rozanolixizumab Biosimilar)

Catalog numberFCRN-AB001

HumanHEK293Molecular weight · 50.81 kDa

Anti-FcRn Antibody (Rozanolixizumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-FcRn Antibody (Rozanolixizumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References