APC-Labeled Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein

Name: APC-Labeled Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein
Brand: Puweituo Bio
SKU: CT83-HP005

Catalog numberCT83-HP005

HumanHEK293Molecule · KK-LC-1

Product introduction

Recombinant APC-Labeled Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. APC-Labeled Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer is assembled by biotinylated monomer and APC-Labeled streptavidin. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILNNFPHSI peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &ILNNFPHSI).

Product details

Molecular aliases: KK-LC-1; CT83; CXorf61; KKLC1;
Protein length: Gly25-Thr305
Expression system: HEK293
Formulation: Supplied as 0.22 μm filtered solution in 100mM L-arginine, 0.2% BSA (pH 7.4).
Storage: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background

Kita-Kyushu lung cancer antigen-1 (KK-LC-1), encoded by CT83, includes epitope peptides recognized by cytotoxic T lymphocytes (CTLs). CTLs against KK-LC-1 predominantly accumulate among tumor-infiltrating lymphocytes, which leads to a good response to adaptive immunotherapy. Except for the testis, KK-LC-1 is not expressed in normal tissues. It is expressed in 33%, 82%, and 75% of non-small cell lung cancers, GC, and triple-negative breast cancers, respectively.

References

1.Otsuka T, Fukuyama T, Futawatari N, Tahara K, Watanabe M, Ichiki Y, Soeno T, Takahashi Y, Yamazaki H, Fujimori Y, Ohshiro T, Kobayashi N, Kida M, Koizumi W, Kusano C. Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition. J Cancer. 2022 Oct 31;13(14):3526-3532. doi: 10.7150/jca.67534. PMID: 36484013; PMCID: PMC9723985.

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APC-Labeled Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein

Catalog numberCT83-HP005

HumanHEK293Molecule · KK-LC-1