Human Claudin 4 VLP Protein

Name: Human Claudin 4 VLP Protein
Brand: Puweituo Bio
SKU: CLDN4-HP001

Catalog numberCLDN4-HP001

HumanHEK293Molecule · Claudin-4Molecular weight · 23.31 kDa

Product introduction

Human Claudin 4 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human Claudin 4 VLP is expressed from HEK293. It contains Met1-Val209 (It may have cross reaction with anti-His antibody) (accession: O14493).

Product details

Molecular aliases: Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8
Protein length: Met1-Val209
Expression system: HEK293
Molecular weight: The target protein has a predicted MW of 23.31 kDa.
Purity: > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

References

1.Fujiwara-Tani R, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Kondoh M, Kuniyasu H. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy. Int J Mol Sci. 2023 Mar 13;24(6):5494. doi: 10.3390/ijms24065494. PMID: 36982569; PMCID: PMC10051602.

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Human Claudin 4 VLP Protein

Catalog numberCLDN4-HP001

HumanHEK293Molecule · Claudin-4Molecular weight · 23.31 kDa