Human CDCP1 (338-667) Protein

Name: Human CDCP1 (338-667) Protein
Brand: Puweituo Bio
SKU: CDCP1-HF002

Catalog numberCDCP1-HF002

HumanHEK293Molecule · CDCP1Molecular weight · 64.2 kDa

Product introduction

Recombinant Human CDCP1 (338-667) Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the N-terminus. It contains amino acid residues Gln338-Thr667 (UniProt accession: Q9H5V8-1).

Product details

Molecular aliases: CDCP1; CD318; SIMA135; TRASK; UNQ2486; PRO5773
Protein length: Gln338-Thr667
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 64.2 kDa. Due to glycosylation, the protein migrates to 75-90 kDa based on Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 0.1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Human CDCP1 (338-667) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human CDCP1 (338-667) is greater than 95% as determined by SEC-HPLC.

Background

Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.

References

1.Wright HJ, Hou J, Xu B, Cortez M, Potma EO, Tromberg BJ, Razorenova OV. CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6556-E6565. doi: 10.1073/pnas.1703791114. Epub 2017 Jul
2.PMID: 28739932; PMCID: PMC5559020.

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Human CDCP1 (338-667) Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References

Human CDCP1 (338-667) Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References